Functional analysis of bacterial type III effector proteins in plants
since 2013 - heute
Many gram-negative plant pathogenic bacteria have acquired a highly conserved type III secretion system (T3SS) which enables them to inject so called type III effector proteins (T3Es) into the plant cell. These T3Es are targeted to a number of cellular compartments where they influence host cellular processes to promote pathogen multiplication and disease. Many T3Es are enzymes (e.g. phosphotransferases, phospholyases, proteases, E3 ligases, and acetyltransferases), while others have no obvious enzymatic activity or act as transcription factors. However, the exact mechanism by which they accomplish their function remains unknown for most of T3Es identified to date.
HopZ4 from Pseudomonas syringae, a member of the HopZ type III effector family from the YopJ superfamily, inhibits the proteasome.
Üstün, S.; König, P.; Gutmann, D.S.; Börnke, F. 2014. HopZ4 from Pseudomonas syringae, a member of the HopZ type III effector family from the YopJ superfamily, inhibits the proteasome. Molecular Plant-Microbe Interactions 27 (7) 611-623.→